Mayo Clinic
This clinical trial evaluates the side effects and possible benefits of operating on brain tumors prior to the tumor coming back (recurrence). Understanding when surgery is most useful to patients with brain tumors is important. Some patients may undergo chemotherapy or radiation but still have visible tumor remaining after treatment. The purpose of this research is to compare outcomes of those who have surgery after chemotherapy or radiation, but prior to tumor recurrence, to those who have surgery at a different time, or no surgery at all.
PRIMARY OBJECTIVE: I. To evaluate the safety and feasibility of surgical resection for pre-recurrent brain tumors. SECONDARY OBJECTIVES: I. To determine whether there are differences in overall survival for patients who receive radiation therapy (RT) prior to surgery as compared to patients who receive RT after surgery or patients undergoing no further surgery. II. To determine for patients having pre-recurrent surgery whether there is a longer interval to local/regional progression, any central nervous system (CNS) progression or need for subsequent intracranial treatment compared to pati…
Inclusion Criteria: * Age \>= 18 years * Histological or cytological confirmation of brain tumor and/or suspected brain tumor based on clinical and radiologic findings * Prior chemotherapy and/or radiation treatment directed to the known/suspected tumor * Radiographic evidence of residual or previously unresected tumor * Willingness to undergo surgery and sign informed consent * Patients not currently eligible for an alternate competing interventional clinical trial * Enrollment in the Mayo Clinic Cancer Center Neuro-Oncology Program Registry for the study of Nervous System Tumors (IRB#12-003…
Undergo surgery
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