Efficacy of Preoperative Administration of Gabapentin in Managing Intraoperative and Postoperative Pain From Third Molar Extractions.
Loma Linda University
Summary
This study is a double-blind, randomized, prospective, placebo-controlled single-center clinical research study in which 600 mg of gabapentin or placebo will be administered 2 hours preoperatively to 49 patients each undergoing wisdom teeth extraction. We will measure intraoperative opioid use, severity of pain, the number of analgesics taken, and side effect profiles (e.g. nausea/vomiting, dizziness) at the following intervals, 4 hour, 8 hour, 12 hour, 24, and 72 hour post-procedure.
Description
Since the 1990s, the amount of prescribed opioids has begun growing. According to the Center for Disease Control, more than 130 people die every day due to opioid overdose. Many medical and surgical specialities have devised various methods to decrease opioid use with adequate pain control. One notable method is preoperative administration of gabapentin. Gabapentin, a prescribed medication, is an anticonvulsant medication used to treat partial seizures, neuropathic pain (e.g. diabetic neuropathy, postherpetic neuralgia, and central neuropathic pain), hot flashes, and restless legs syndrome .…
Eligibility
- Age range
- 18–59 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Subjects must be at or older than 18. * Screened body mass index (BMI) between 18-35 kg/m2. * American Society of Anesthesiologists Classification I and II. * Subjects must be willing and able to comply with protocol requirements. * Subjects must be able to understand the informed consent and must be able to sign a written informed consent form prior to the initiation of any study procedures. * A subject must have at least 1 partial or fully impacted third molar tooth removal. Exclusion Criteria: * hypersensitivity to gabapentinoids; * history of chronic opioid or gaba…
Interventions
- DrugGabapentin 600mg
The patient will take gabapentin 600mg 2 hours prior to the procedure
- DrugPlacebo
the patient will take a pill that looks like gabapentin 2 hours prior to the procedure
Location
- Loma Linda University HealthLoma Linda, California