Transdiagnostic Cognitive Biomarkers
University of Minnesota
Summary
The overall objective of this study is to determine the feasibility of identifying transdiagnostic biomarkers of cognitive function mediated by neuromodulation of the dorsolateral prefrontal cortex that are translatable across disease groups in order to more accurately phenotype clusters of cognitive dysfunction. Completing behavioral paradigms with electrophysiology and TMS is a challenging frontier. This study focuses on the feasibility of such an endeavor for those with chronic pain or depression as well as healthy controls.
Description
This study aims to test the feasibility of procedures aimed at discovering transdiagnostic biomarkers for cognitive impairment in chronic pain and depression. Fifteen healthy control participants and 15 participants from each disease group (chronic pain, depression) will be recruited. Using a task-based fmri, TMS will be targeted for priming of the Left DLPFC. EEG will be used during our behavioral paradigm to compare changes in DLPFC function before and after primed TMS.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Arm 1, healthy controls: Inclusion Criteria: * Have access to the online study platform. Exclusion Criteria: * under 18, non-English speaking Arm 2: pain and depression: Inclusion Criteria: * Pain or depression Exclusion Criteria: * pregnant women
Interventions
- BehavioralComputer game/task
N-back, COGED, PacMan game, Bandit task, Websurf task.
- BehavioralHealth surveys online
Health surveys to study themes like pain, sleep, depression and anxiety, and PTSD.
Location
- University of MinnesotaMinneapolis, Minnesota