The Cleveland Clinic
The goal of the proposed research is to investigate Magnetic Resonance (MR) Fingerprinting and P-MRS (Phosphorus-31 MR Spectroscopy) imaging for characterization of skeletal muscle in heart failure patients with sarcopenia. Heart failure patients with and without sarcopenia will be scanned using MR Fingerprinting and an existing Post-exercise phosphocreatine (PCr) recovery MR imaging protocol to obtain characteristic profiles of quantitative T1, T2, and PCr recovery rate.
Sarcopenia is a common comorbidity and predictor of mortality in heart failure that is characterized by a loss of muscle mass and functional strength. Sarcopenia, in heart failure and other chronic diseases, has been consistently predictive of poor outcomes. However, current tools to identify the presence of sarcopenia, such as functional tests and questionnaires are indirect, non-specific, and not effective until patients have reached an overtly cachectic state and significant muscle deterioration has already occurred. MRI can serve an important, noninvasive role in the assessment and managem…
Inclusion Criteria: * Heart failure patients * Age ≥40 yrs * Stable chronic heart failure * Systolic dysfunction determined by cardiac MRI with left ventricle ejection fraction 40% or less * Healthy Volunteers * Age ≥40 yrs * No diagnosed heart failure or sarcopenia Exclusion Criteria: * Heart failure patients • Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease * Healthy volunteers (controls) * Advanced liver disease, advanced cancer, advanced chronic obstructive pulmonary disease * Contraindications to MRI Contraindications to MRI…
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