Neural Correlates of Real World Spatial Navigation in Humans
Duke University
Summary
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Eligibility
- Age range
- 12–70 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * 12 years of age or older and has undergone RNS system placement * Willing to provide informed consent and participate the study * Ability to read and write English fluently Exclusion Criteria: * Unwilling to provide informed consent
Interventions
- DeviceDeep Brain Stimulation
Deep brain stimulation will be used
- BehavioralMemory and spatial navigation tasks
Tasks may include walking around the room, on a treadmill, or in a controlled environment using VR (virtual reality) or AR (augmented reality) technology designed to simulate real-world navigation. Participants may also use Meta Ray-Ban glasses to capture new memories while recording neural activity.
- BehavioralPhysiological Signals
Physiological signals such as heart rate, respiration, and skin conductance will be monitored while completing lab tasks. Motion capture and eye-tracking may also be used.
- BehavioralQuestionnaires and Assessments
Participants complete questionnaires and assessments to assess subjective emotional experience.
Locations (2)
- University of California, Los AngelesLos Angeles, California
- Duke UniversityDurham, North Carolina