Prospective Evaluation of Topical Almond Oil vs Hydroquinone on the Appearance of Facial Pigmentation and the Stability of the Microbiome
University of California, Davis
Summary
The purpose of this study is to analyze facial pigmentation and skin microbiome changes after topical almond oil application, compared to the use of topical hydroquinone.
Description
The purpose of this experiment is to analyze facial pigmentation and skin microbiome changes after topical almond oil application, compared to the use of topical hydroquinone. There will be a total of 50 subjects: * 25 randomized to receive almond oil nightly * 25 randomized to receive 2% hydroquinone nightly Study Timelines: * The duration of an individual subject's participation will last from the day of the consent/screening (visit 1) until visit 5 where they will have images taken and measurements collected to assess skin pigment, skin hydration, sebum excretion rate. * The duration of…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Premenopausal women of Fitzpatrick skin types 3 to 6 Exclusion Criteria: * Those with a nut allergy * Smoking is an independent risk factor and serves as a confounder for the development of facial aging \[18\]. Therefore current smokers, those that have smoked within the past year, and former smokers with greater than a 20 pack year history of smoking will be excluded. * Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndrome) will be excluded as this can be a confounder for…
Interventions
- OtherAlmond Oil
Almond oil
- DrugHydroquinone Topical
Hydroquinone 2% cream
Location
- UC Davis Department of Dermatology, Clinical Trials UnitSacramento, California