Medical College of Wisconsin
This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.
PRIMARY OBJECTIVES: I. Examine associations between social support, strain, and isolation and phenotypic aging over the 1-year recovery period. II. Examine associations between social support, strain, and isolation and biological aging over the 1-year recovery period. III. Test biological aging as a mediator linking social processes and phenotypic aging. EXPLORATORY OBJECTIVE: I. Test sex differences in Aims 1 and 2. OUTLINE: Adopting a prospective design, participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of so…
Inclusion Criteria: * Aged 18 years and older who are competent to give their informed consent. * Ability to read, speak, and understand English. * Received a hematopoietic cell transplant within the previous 100 days. Exclusion Criteria: * Less then Aged 18 years and older who are competent to give their informed consent. * Cannot read, speak, and understand English. * Has not received a hematopoietic cell transplant within the previous 100 days.
Undergo collection of blood sample
Review of medical records
Complete questionnaires
Arctuva estimate
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