Accelerated Biological and Phenotypic Aging in Hematopoietic Cell Transplant Survivors: Social Support as a Protective Factor
Medical College of Wisconsin
Summary
This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.
Description
PRIMARY OBJECTIVES: I. Examine associations between social support, strain, and isolation and phenotypic aging over the 1-year recovery period. II. Examine associations between social support, strain, and isolation and biological aging over the 1-year recovery period. III. Test biological aging as a mediator linking social processes and phenotypic aging. EXPLORATORY OBJECTIVE: I. Test sex differences in Aims 1 and 2. OUTLINE: Adopting a prospective design, participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of so…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Aged 18 years and older who are competent to give their informed consent. * Ability to read, speak, and understand English. * Received a hematopoietic cell transplant within the previous 100 days. Exclusion Criteria: * Less then Aged 18 years and older who are competent to give their informed consent. * Cannot read, speak, and understand English. * Has not received a hematopoietic cell transplant within the previous 100 days.
Interventions
- ProcedureBiospecimen Collection
Undergo collection of blood sample
- OtherElectronic Health Record Review
Review of medical records
- OtherQuestionnaire Administration
Complete questionnaires
Location
- Froedtert Hospital and the Medical College of WisconsinMilwaukee, Wisconsin