Genetic Studies of Early-onset Dementia
Columbia University
Summary
The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.
Description
The study population includes individuals with Alzheimer's disease, mild cognitive impairment, other forms of dementia, as well as cognitively healthy individuals with a family history of dementia. Participants include males and females across all racial and ethnic groups.
Eligibility
- Age range
- 35+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion criteria: * 35 years and older * Individuals experiencing memory concerns or diagnosed with dementia and their family members that are unrelated healthy controls without dementia. Exclusion Criteria: \- Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual
Interventions
- GeneticBlood draw
Blood draw for identification of genetic variants associated with the development of memory problems
- OtherNeurocognitive testing
Brief memory test
- OtherMedical questionnaire
Collection of medical history
Location
- Columbia University Irving Medical CenterNew York, New York