White Button Mushroom and Biomarkers of Immune Cell and Inflammatory Responses in Obese Postmenopausal Women at High Risk of Breast Cancer
City of Hope Medical Center
Summary
This clinical trial studies the effects of dietary white button mushroom on inflammation (the body's process of fighting against harmful things) and immune cells (white blood cells) in postmenopausal women with both high body mass index or BMI (percentage of body fat) and high risk of breast cancer. The body is in a constant state of alert when inflammation lingers at a low level and becomes chronic, as with having button mushroom is a dietary supplement that may improving responses of immune cells (white blood cells) and decreasing chronic inflammation. Information gathered from this study may help researchers determine whether white button mushroom have any effects on body fat and breast cancer risk.
Description
PRIMARY OBJECTIVE: I. To determine effects of white button mushroom (WBM) on circulating immune cell profiles, and specifically myeloid-derived suppressor cells (MDSCs), in obese (BMI \>= 30 kg/m\^2, Asian BMI \>= 25 kg/m\^2) postmenopausal women at high risk of breast cancer. SECONDARY OBJECTIVES: I. To evaluate changes in circulating biomarkers of inflammation. II. To evaluate changes in immune cell profiles and inflammation in breast adipose tissue samples. III. To evaluate tolerability of WBM in a study cohort of obese postmenopausal women. IV. To evaluate changes in BMI, central adip…
Eligibility
- Age range
- 21+ years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * This study will be conducted in postmenopausal women who have increased risk of breast cancer and high BMI \>= 30 kg/m\^2 * The study population will consist of women with a relative risk of developing breast cancer that is at least \> 2 x that of the general population for their age group based on any of the following: * Have a known genetic mutation associated with hereditary breast cancer (including BRCA1, BRCA2, p53, etc.) * One or more first degree relatives with breast cancer, with at least one under the age of 60 * Two or more second degree relatives with b…
Interventions
- OtherQuestionnaire Administration
Ancillary studies
- DrugWhite Button Mushroom Extract
Given PO
Location
- City of Hope Medical CenterDuarte, California