All-extremity Exercise as a Novel Strategy for Optimizing Cardiovascular Function During Chemotherapy for Breast Cancer
University of Florida
Summary
Currently, there are 3.5 million breast cancer survivors in the United States and this number is expected to increase dramatically. The proposed research will examine whether a novel exercise intervention for breast cancer patients who are undergoing chemotherapy protects against cardiovascular dysfunction. Findings may have implications for cardiovascular disease prevention in this population.
Eligibility
- Age range
- 18–85 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Active diagnosis of primary invasive non-metastatic breast cancer, stages I-III * Female * 18 to 85 years of age * Scheduled to initiate neoadjuvant or adjuvant chemotherapy (anthracycline, alkylating agent and/or taxane) * Absence of contraindications to exercise * Study clinician approval * Able to give consent * Informed consent obtained from the subject and documentation of subject agreement to comply with study-related process Exclusion Criteria: * Do not meet inclusion criteria * Receiving targeted therapies (CDK4/6 or PARP inhibitors) * Receiving radiation thera…
Interventions
- BehavioralExercise training
Exercise training performed at home under remote live supervision over 12 weeks while patients undergo chemotherapy for breast cancer.
Location
- Integrative Cardiovasculal Physiology Laboratory, University of FloridaGainesville, Florida