Time-restricted Feeding to Mitigate Metabolic Impairments During Circadian Misalignment
Colorado State University
Summary
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.
Description
People who work evening, night or rotating shifts (i.e. "nonstandard" work hours) represent one in five U.S. employees and are alarmingly 44% more likely to develop Type 2 diabetes (T2D) compared to people who work standard day shifts. Circadian misalignment is one mechanism suggested to increases the risk of obesity and diabetes in people who work non-standard hours, and is highly prevalent and often unavoidable in modern, 24-hour society (e.g. shift work, long work hours, jet lag, medical residency, emergency responders, military personnel, Daylight Savings Time changes, etc). Disruptions in…
Eligibility
- Age range
- 18–35 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. 18-35 old; men and women; equal numbers of women and men will be included. 2. Body Mass Index (BMI) between 20.0 and 24.9 ("normal" weight). 3. Physical activity history: inactive to habitual moderate physical activity level 4. Sleep/wake history: habitual sleep duration between 7-9.25 hours. 5. Altitude history: Potential subjects must have lived at Denver altitude or higher for at least 3 months prior to inpatient stay. Exclusion Criteria: 1. Any clinically significant medical, psychiatric, or sleep disorder 2. Use of prescribed medications/supplements/illicit drugs…
Interventions
- BehavioralTime-restricted feeding
Each subject will participate in both conditions (CM and CM+TRF)--one in which food is allowed during the nighttime period and one in which food will be restricted to the daytime only. Food intake will be matched across conditions and designed to keep participants weight stable.
- BehavioralCircadian Misalignment
Healthy lean subjects will undergo circadian misalignment induced using a simulated night shift-work protocol in both conditions of the study. Each condition will last approximately 6 days.
Location
- Colorado State UniversityFort Collins, Colorado