Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children
University of Colorado, Denver
Summary
The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.
Description
The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition. The global hypothesis is that childhood cancer survivors with prior exposure to systemic vincristine (VCR) and/or doxorubicin (DOX) report an increased incidence of bladder dysfunction (BD) symptoms on the Dysfunctional Voiding Symptom Score (DVSS) survey. We expect to observe differences in non-invasive urodynamic (niUDS) testing between childhood cancer survivors with BD symptoms on the DVSS versus those without BD s…
Eligibility
- Age range
- 5–13 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Children aged 5-13 years old * A history of cancer * Treatment with a chemotherapy regimen including VCR and/or DOX * Completion of chemotherapy at least one year prior to study enrollment and survey completion. Exclusion Criteria: * Patients with a: * Primary pelvic tumor * Pelvic irradiation * Pre-existing bladder/bowel dysfunction * Spinal defects * Neurologic disorder * Neuro-oncologic tumor or brain metastasis * Cyclophosphamide or ifosfamide therapy
Interventions
- Diagnostic TestNon-invasive Urodynamic Test (niUDS)
A noninvasive urodynamics is a simple test used to evaluate urinary flow.
- Diagnostic TestUrinary proteomic screen
Urine proteomics is a powerful platform to identify urinary excreted proteins and peptides in different stages of disease or therapy and to determine their quantity, functions, and interaction.
- OtherDysfunctional Voiding Symptom Score Survey (DVSS)
The Dysfunctional Voiding Symptom Score provides accurate and objective grading of voiding behaviors of children.
Location
- Children's Hospital ColoradoAurora, Colorado