Neurocognitive Outcomes After Whole Brain Radiation Therapy for Hematologic Malignancies
M.D. Anderson Cancer Center
Summary
This study assesses neurocognitive outcomes after receiving radiation therapy to the brain (whole brain radiation therapy) in patients with blood cancers (hematologic malignancies). This may help researchers learn more about the effects of whole brain radiation therapy on memory and thinking in patients with blood cancer.
Description
PRIMARY OBJECTIVE: I. Record patients' cognitive outcomes after whole-brain radiation therapy (WBRT) for hematologic malignancies using standard-of-care neurocognitive function testing. SECONDARY OBJECTIVES: I. Assess patients' quality-of-life after WBRT for hematologic malignancies, based on a validated questionnaire. II. Explore magnetic resonance imaging (MRI) changes in the brain after WBRT for hematologic malignancies, based on standard-of-care imaging studies. III. Study the role of Memantine in patients' cognitive outcomes during and after WBRT for hematologic malignancies, based o…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age 18 years or older * Treatment with radiation therapy to the brain for a hematologic malignancy (ex. primary central nervous system lymphoma \[PCNSL\], secondary central nervous system lymphoma \[SCNSL\], leukemia, myeloma) * Proficient and capable of completing tests in English * Patients with claustrophobia are eligible if the claustrophobia is managed with medication * Patients with cognitively-impairment are eligible if the impairment is managed with medication * Patients who are pregnant
Interventions
- ProcedureMagnetic Resonance Imaging
Undergo MRI
- OtherNeurocognitive Assessment
Undergo neurocognitive function assessment
- OtherQuality-of-Life Assessment
Complete questionnaires
- OtherQuestionnaire Administration
Complete questionnaires
Location
- M D Anderson Cancer CenterHouston, Texas