Antiseptic Effects on the Dental Implant Internal Surface Microbiome
Madigan Army Medical Center
Summary
Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.
Description
Clinical Background Peri-implantitis/mucositis is bone loss/tissue inflammation around a dental implant. This is caused by bacterial biofilm at the interface between the implant and bone/tissue. The source of bacteria comes from the internal surface of the implant, and leaks through the implant/abutment interface. After the dental implant is placed in bone, bacteria from the saliva and blood within the internal surface of the implant leak out. The body reacts to this bacterial exposure with inflammation, resulting in bone loss around the implant/abutment interface. Warfighters are exposed to…
Eligibility
- Age range
- 18–55 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Active duty military * 18-55 years old * Over 6 months remaining at local duty station Exclusion Criteria: * Tobacco user * Medications that affect soft tissue or bone healing * Metabolic disorder that affects soft tissue or bone healing * Active periodontal disease
Interventions
- DrugChlorhexidine
Chlorhexidine will be inserted into the dental implant internal cavity during dental implant insertion.
- DrugHydrogen Peroxide
Hydrogen Peroxide will be inserted into the internal cavity of the dental implant during dental implant insertion.
Location
- Madigan Army Medical CenterTacoma, Washington