Association Between Serum Testosterone Levels and Cutibacterium Culture Positivity During Shoulder Arthroplasty
University of Washington
Summary
Phase 1: In 51 patients undergoing shoulder arthroplasties, total serum testosterone, free testosterone and sex hormone binding globulin levels obtained in the clinic before surgery were correlated with the levels of Cutibacterium on the skin in clinic, in the operating room prior to surgery, and in the skin incision. Phase 2: The investigators wish to determine if preoperative serum testosterone levels are associated with risk for shoulder PJI (periprosthetic joint infection) in patients undergoing primary shoulder arthroplasty. Also to determine if preoperative serum testosterone levels are predictive of bacterial load of deep tissue cultures taken at the time of revision shoulder arthroplasty in patients undergoing primary shoulder arthroplasty.
Description
Phase 1: 51 patients having elective shoulder arthroplasty were offered the opportunity to participate, consented and enrolled in this prospective clinical cohort study. At a preoperative clinic visit, basic demographic information was collected along with the patient's response to a question about taking supplemental testosterone. A swab of the unprepared skin over the area of the intended surgical incision was obtained and sent for culture. At this clinic visit, a sample of the patient's blood was also obtained and submitted to our clinical laboratory for the levels of total serum testoster…
Eligibility
- Age range
- 18–89 years
- Sex
- All
- Healthy volunteers
- No
Phase 1 Inclusion Criteria: * Patients having elective shoulder arthroplasty Phase 1 Exclusion Criteria: * history of shoulder septic arthritis * antibiotic use within 3 months prior to surgery * recent treatment for acne * Lacked fluency in English Phase 2 Inclusion Criteria: * Patients having elective shoulder arthroplasty Phase 2 Exclusion Criteria: * Lacked fluency in English
Location
- University of WashingtonSeattle, Washington