Topography-guided vs. Wavefront Optimized Corneal Refractive Surgery: A Prospective Contralateral Randomized Double-masked Study
59th Medical Wing
Summary
This is a prospective randomized contralateral double-masked study. Each patient will be randomized as to which eye undergoes wave-front optimized (WFO) vs. wave-front guided (WFG) during Photorefractive keratectomy (PRK) or Laser-assisted in situ Keratomileusis (LASIK) surgery to determine which ablation profile provides the best visual outcome.
Description
In 2015, the FDA approved a new laser ablation profile for performing laser corneal refractive surgery. Multiple sophisticated profiles have been developed in an attempt to optimize visual outcomes and reduce post-operative lower and higher-order optical aberrations. Among these include wave-front optimized (WFO) and wave-front guided (WFG) ablation profiles. The former compensated for corneal curvature to reduce spherical aberration and the latter, a more complicated ablation profile, was designed to minimize specific aberrations in an individual eye. Topographic profiles have also been used…
Eligibility
- Age range
- 21–50 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Meet requirements for PRK or LASIK i.e., Stable \<= .5 D change MRSE) * DOD beneficiaries age 21-50 years * Local pts (w/i 60 mi) who will be in the area for at least 6 months post surgery * Willing to complete all required follow-up visits Exclusion Criteria: * No meeting requirements for PRK or LASIK * Desiring monovision treatment * Anisometropia \>2D spherical equivalent * Prior ocular surgeries / trauma / problem * History of dry eyes * Hyperopia * Mixed astigmatism * Inability to capture VARIO topolyzer scans * Pregnant (or who plans to be within 6 months after s…
Interventions
- DeviceWave-Front Optimized (WFO) ablation vs Topography-guided (TG) ablation
Patient will undergo PRK or LASIK using WFO ablation in one eye and TG ablation on contralateral eye
Location
- Joint Warfighter Refractive Surgery Center at WHASCSan Antonio, Texas