CPRIT: Optimizing Surgical and Rehabilitation Treatment of Pelvic Sarcomas Using Computational Models
M.D. Anderson Cancer Center
Summary
This trial studies the development of patient-specific computational walking models to improve the surgical planning and rehabilitation treatment of patients with pelvic sarcomas. Every pelvis and pelvic sarcoma are different, and the orthopedic oncologist faces significant challenges when removing a tumor from the complex anatomy of the pelvis. These challenges make it difficult to achieve excellent oncological and functional outcomes together. Computational walking models may be used to predict the best combination of surgical methods and how to implement them to maximize each patient's post-surgery walking function.
Description
PRIMARY OBJECTIVES: I. To develop patient-specific computational walking models to predict the optimal combination of pelvic sarcoma surgical and rehabilitation decisions that will maximize each patient's post-surgery walking function. II. To collect experimental movement and imaging data prospectively and retrospectively from individuals who have already received, or are going to receive, a type I or type II hemipelvectomy. III. To use the data to develop computational modeling and simulation methodologies that can predict an individual patient's post-surgery walking function given pre-sur…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Patients who have received or are scheduled to receive an internal hemipelvectomy with or without reconstruction at UT MD Anderson Cancer Center. 2. Patients who are 18 years of age and older Exclusion Criteria: 1. Patients who have undergone an external (hindquarter amputated), or an isolated type III internal hemipelvectomy. 2. Previous surgery or significant injury to either hip (prospective patients only) 3. Relevant surgery, procedure, injury, or condition in the last two years which may affect hip pain or general movement patterns on either side (prospective pat…
Interventions
- OtherFunctional Assessment
Undergo walking function assessment with optical motion capture
- ProcedureX-Ray Imaging
Undergo bi-plane dynamic X-ray imaging
Location
- M D Anderson Cancer CenterHouston, Texas