M.D. Anderson Cancer Center
This study examines the long-term effects of tamoxifen (TAM) treatment on excessive production of neutrophil extracellular traps (NET) and their impact on breast cancer and side effects. NET are produced by the body to fight infections but have also been linked to side effects caused by the body's immune system. Treatment with tamoxifen increases the production of NETs. This study may help researchers determine if the increased number of NETs in the body has a damaging effect in breast cancer.
PRIMARY OBJECTIVE: I. To examine the effect of long-term tamoxifen (TAM) treatment on excessive NET formation in breast cancer patients. SECONDARY OBJECTIVES: I. To understand the molecular mechanisms of tamoxifen-induced NET formation in breast cancer patients by examining the effect of long-term TAM treatment on the NET-induced factors. II. To correlate the extend of NET formation with clinical data on tamoxifen resistance, drug side-effects, cancer metastasis and comorbidities. EXPLORATORY OBJECTIVE: I. To explore the association between the extent of NET formation and clinical data f…
Inclusion Criteria: * Female * Age criteria for pre-menopausal group: Equal to or greater than 18 years of age and less than or equal to 45 years of age. Patients of age 46-50 will be included if they have not had menstrual cessation for 12 consecutive months. * Age criteria for menopausal group: At least 51 years of age (median age of menopause). Menopause is defined as cessation of menstrual cycle for 12 consecutive months. * Diagnosed with ER+ breast cancer * Being treated with tamoxifen (TAM) for at least 6 months * CONTROL SUBJECTS: Newly diagnosed ER+ breast cancer patients of the same…
Undergo collection of blood sample
Medical charts are reviewed
Arctuva estimate
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