Pilot Study of Pancreatic Cancer Screening
University of California, San Francisco
Summary
This study investigates how often abnormal findings from routine magnetic resonance imaging occur in people with genetic mutations in BReast CAncer gene. (BRCA), ataxia telangiectasia mutated gene (ATM), or PALB2 screened for pancreatic cancer. This study may lead to a greater understanding of cancer and potentially, improvements in cancer screening and treatment.
Description
PRIMARY OBJECTIVE: I. To determine the event rate of abnormal magnetic resonance imaging (MRI) and Endoscopic ultrasound (EUS) findings in screened study participants. SECONDARY OBJECTIVES: I. To determine the rates of high-grade pancreatic neoplasia precursors (intraductal papillary mucinous neoplasm (IPMN)-high-grade dysplasia (HGD)) and pancreatic intraepithelial neoplasia-3 \[PanIN-3\]) and pancreatic ductal adenocarcinoma (PDAC) among all study participants. II. To understand rates of procedures (biopsies and surgeries) among all study participants. EXPLORATORY OBJECTIVES: I. To cre…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Ability to provide consent and willing, and able to comply with study procedures Ability to read and speak English GROUP I: * Documentation of pathogenic or likely pathogenic germline BRCA 1 and 2, ATM or PALB2 germline genetic mutation * No strong family history of pancreatic cancer (defined as having \>= 1 first-degree or second-degree relative with a history of pancreatic cancer) * Age \>= 50 years old at time of consent. GROUP II: * Documentation of pathogenic or likely pathogenic germline BRCA 1 and 2, ATM, or PALB2 germline genetic mutation * Has strong family hi…
Interventions
- ProcedureBiospecimen Collection
Undergo blood, tissue, and saliva collection
- ProcedureMagnetic Resonance Cholangiopancreatography
Undergo MRCP
- ProcedureMagnetic Resonance Imaging
Undergo MRI
- ProcedureEndoscopic ultrasound
Undergo endoscopic ultrasound
- OtherQuestionnaires
Complete the following questionnaires: Pancreatic Cancer Knowledge Survey, Pancreatic Cancer Worry Scale, Disease Specific Perceived Risk Survey, eGene Questionnaire
Location
- University of California San FranciscoSan Francisco, California