Locomotor Recovery and Compensation Post-stroke (LRC)
Indiana University
Summary
The proposed research will characterize of the time course of neurological and locomotor recovery as well as development of compensatory strategies throughout sub-acute and chronic phases post stroke. In addition, we will also investigate the extent to which measures of recovery and compensation are malleable and can be altered with specific interventions in both the early and late stages post-stroke. Delineation of the time course of development and magnitude of patterns of recovery and compensation should result in alternative predictive "rules' regarding how patients early post-stroke could recovery functional and neurological function.
Description
Recovery of locomotion is a primary goal of rehabilitation post-stroke and a major determinant of future morbidity and mortality. While substantial recovery is observed early post-stroke, recent evidence suggests the magnitude and time course of recovery is deterministic and based primarily on initial motor deficits. The "proportional recovery" rule suggests \~70% of neurological recovery (measured by the lower limb Fugl-Meyer Assessment - LL-FMA) is typically achieved and is not influenced by the dosage of therapy. These findings suggest the physical interventions applied to patients are of m…
Eligibility
- Age range
- 18–85 years
- Sex
- All
- Healthy volunteers
- No
Inclusion criteria: * individuals early post-stroke (\<15-30 days) * first ever stroke * unilateral hemiparesis * currently receiving inpatient rehabilitation * ability to follow 1-step commands * provision of informed consent * medical clearance from the rehabilitation physician to participate. \\ Exclusion criteria: * uncontrolled cardiovascular, metabolic or respiratory disease that limits exercise participation (e.g., congestive heart failure, resting blood pressure \> 200/110 mmHg, uncontrolled diabetes, end-stage renal disease) * absolute criteria for termination of exercise testing d…
Interventions
- Behavioralhigh-intensity training focused on stepping in variable contexts
Approximately 10 weeks (\~30 sessions) of high-intensity training
Location
- Rehabilitation Hospital of IndianaIndianapolis, Indiana