Brain Metabolism Observed at 3 Tesla or 7 Tesla in Health and Metabolic Disease
Weill Medical College of Cornell University
Summary
The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla or 3 Tesla.
Description
The goal is to establish a protocol to 13C-label (from 13C-glucose) several physiological molecules: glucose, lactate, pyruvate and derived compounds. All of these molecules can undergo oxidation in the citric acid cycle. The intent is to study the 13C labeling pattern of these molecules in control and G1D subjects to determine if downstream products (such as 13C bicarbonate or 13C glutamate) due to oxidation in the mitochondria can be detected in brain or in blood by NMR analysis. While inside the instrument, the subjects may also undergo a 7T MR or 3T MR exam to correlate spectroscopy with b…
Eligibility
- Age range
- 16–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Subjects will be adolescents or adults, age 16-80 years in good general health (evidenced by normal vital signs and no acute signs or symptoms of illness) or with previously (not for this study) documented G1D (genetically confirmed). 2. Ages 16 to 80 3. Persons with dental fillings, dental crowns, and short (max.4 cm) dental retainer wires can be included. Exclusion Criteria: 1. People or patients with uncontrolled seizure disorder, defined as grand mal (not absence) seizure in the preceding 3 months. 2. Pregnant females will be excluded. A serum or urine pregnancy t…
Interventions
- DeviceMagnetic resonance imaging
Medical imaging technique used in radiology to form pictures of the anatomy.
Locations (2)
- Weill Cornell MedicineNew York, New York
- UT Southwestern Medical CenterDallas, Texas