Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
University of California, San Diego
Summary
Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to the progression of Alzheimer's disease.
Description
Aim 1: We will assess the endotypes (mechanisms) underlying OSA in elderly individuals known to be high risk for AD (vs. non-OSA matched controls) using novel recently validated simplified techniques which do not require burdensome complex overnight experiments to assess endotypes (primary outcome loop gain). We will further assess the predicted response to O2 therapy in terms of respiratory outcomes among elderly OSA patients with varying levels of loop gain and pharyngeal collapsibility. Hypothesis 1: A substantial proportion of high AD risk patients with OSA should be O2 responsive as pred…
Eligibility
- Age range
- 65–85 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age 65-85 years 2. Gender: Men or Women 3. MOCA \> 26 4. Independently living and able to drive 5. OSA (AHI ≥ 15/h) or no OSA 6. Subjects must consent to waiving their right to obtain their PHS score (since the score is not yet actionable and could lead to social stress and ethical dilemmas) Exclusion Criteria: 1. Currently smoking 2. History of COPD or asthma 3. Heart Failure Class III or IV, unstable cardiovascular disease, or uncontrolled hypertension 4. Neuromuscular Disease 5. Drowsy Driving (ESS \> 18/24) 6. Inability to complete study procedures, such as questi…
Interventions
- OtherSupplemental Oxygen
Subjects will be instrumented with a nasal cannula to receive 2L/min supplemental oxygen. The oxygen will be kept at a fixed rate, however, the participant will be titrated to receive a max of 4 liters per min to maintain sats \>90% based on oximetry readings.
- DeviceContinuous Positive Airway Pressure Machine
Continuous positive airway pressure is a form of positive airway pressure ventilation in which a constant level of pressure greater than atmospheric pressure is continuously applied to the upper respiratory tract of a person.
- OtherRoom Air
Subjects will be instrumented with a nasal cannula to receive 2L/min pressurized room air. The room air will be kept at a fixed rate, however, the participant will be titrated to receive a max of 4 liters per min to maintain sats \>90% based on oximetry readings.
Location
- UCSD Sleep ResearchLa Jolla, California