Hypofractionated Radiation Therapy for Merkel Cell Carcinoma
M.D. Anderson Cancer Center
Summary
This phase II trial tests whether hypofractionated radiation works to treat patients with Merkel cell carcinoma. Radiation therapy uses high energy radio waves to kill cancer cells and shrink tumors. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may be more convenient for patients and less immunosuppressive.
Description
* To estimate the 2-year local control rate for adjuvant hypofractionated RT to the primary tumor bed. * To estimate the 2-year nodal control rate for adjuvant hypofractionated RT to the primary draining nodal basin. Secondary Objectives * To determine MCC disease outcomes including:time to non-nodal locoregional recurrence, time to nodal recurrence, time to distant mestasis, disease-free-survival and disease-specific survival for patients receiving hypofractionated adjuvant RT. * To assess acute and late RT associated toxicity within or neighboring the radiated field.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients must have histologically or cytologically confirmed MCC. * Patients must have no evidence of distant metastasis as determined by clinical examination and any form of imaging. * If planned for adjuvant primary tumor radiation therapy a patient should have had surgical excision of a primary MCC tumor within 4 months of starting RT. * If planned for adjuvant nodal radiation therapy a patient should have had: * Prior positive sentinel lymph node biopsy with any degree of nodal involvement within 4 months of starting RT and no completion nodal dissection, or * L…
Interventions
- DrugRadiation therapy
Hypofractionated radiation therapy to the primary tumor and/or lymph nodes
Location
- M D Anderson Cancer CenterHouston, Texas