Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
University of Pennsylvania
Summary
Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.
Description
The investigators and others have shown that the first influenza virus someone is exposed to leaves an immunological imprint that affects antibody responses to antigenically related influenza strains later in life. Year of birth can be used to predict influenza virus exposures during the first years of life. It is possible that immune responses to influenza vaccination later in life differ between people with different birth years, depending on what virus someone was "imprinted" with. This could result in birth year differences in antibody responses upon vaccination and vaccine effectiveness.…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for all study visits 3. Aged 18 years and older 4. In good health based on self-reported medical conditions via an online survey Exclusion Criteria: 1. Known allergic reactions to components of the study vaccine 2. Known latex allergy 3. History of severe reactions following previous immunization with licensed or unlicensed influenza virus vaccines 4. History of GBS within 6 weeks of receipt of a previous influenza vaccine 5. Immunosuppression…
Interventions
- BiologicalSeasonal influenza vaccine
The seasonal influenza vaccine is administered intramuscularly at a dose of 15 ug of HA per component, as approved by the FDA.
Location
- University of PennsylvaniaPhiladelphia, Pennsylvania