Mayo Clinic
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
This is a randomized, double-blind, placebo-controlled, parallel-arm, dose escalation study of Duloxetine \& Amitriptyline in subjects with refractory chronic cough. Subjects will be screened during a period of up to 2 week and will undergo screening/ baseline cough monitoring. A total of 50 subjects who meet entry criteria will be randomly assigned in a 1: 1: 1: 1: 1 ratio to one of five treatment arms using stratified randomization in blocks of 10. Each arm will have two successive 4-week treatment periods (Blinded Period 1 \& 2). After this, patients will be unblinded and receive routine cl…
Inclusion Criteria * Chest radiograph or computed tomography (CT) of the thorax within the last 1 year not demonstrating any abnormality considered to be significantly contributing to the refractory chronic cough in the opinion of the Principal Investigator * Have a diagnosis of refractory chronic cough or unexplained cough for at least one year according to the American College of Chest Physicians guidelines * Have a score of ≥ 40mm on the Cough Severity VAS at Screening. * Women of child-bearing potential must agree to use 2 forms of acceptable birth control and make no donation of eggs fro…
30mg orally for 4 weeks
60mg orally for 4 weeks
25 mg orally for 4 weeks
50 mg orally for 4 weeks
30mg tablet with no active study ingredient for 4 weeks
60mg tablet with no active study ingredient for 4 weeks
Arctuva estimate
Verify or correct the compensation shown for this listing.