Testing the Contribution of Orbitofrontal Cortex Networks to Decision-making
Northwestern University
Summary
This research study examines the contribution of orbitofrontal cortex (OFC) networks to decision-making.
Description
This study will combine functional magnetic resonance imaging (fMRI), non-invasive transcranial magnetic stimulation (TMS), olfactory stimuli, and a devaluation task to define the specific contributions of orbitofrontal cortex (OFC) networks in outcome-guided behavior. We will use network-targeted TMS to modulate activity within anterior OFC and posterior OFC networks, examining if they have different contributions to decision-making. This is a randomized, between-subjects design.
Eligibility
- Age range
- 18–40 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age between 18 and 40 years old * Right-handed * Fluent English speakers Exclusion Criteria: * History of significant neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.) * History of major psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, substance use disorder, etc.) * Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.) *…
Interventions
- DeviceReal transcranial magnetic stimulation (TMS) before conditioning
Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the conditioning phase of the task.
- DeviceReal transcranial magnetic stimulation (TMS) before devaluation test
Real TMS will be applied using the MagVenture MagPro X100 stimulator with the active side of the Cool-B65 A/P coil before the devaluation test phase of the task.
- DeviceSham transcranial magnetic stimulation (TMS)
Sham TMS will be applied using the MagVenture MagPro X100 stimulator with the placebo side of the Cool-B65 A/P coil.
Location
- Northwestern UniversityChicago, Illinois