A Neurocomputational Assay of Gastrointestinal Interoception in Anorexia Nervosa
Laureate Institute for Brain Research, Inc.
Summary
Anorexia nervosa (AN) has among the highest mortality rate of any psychiatric illness, yet we have a poor understanding of the biological causes of this disorder. In this study, we use a novel mechanosensory intervention to examine the basic question of whether individuals with AN have abnormal "gut sensations" and whether such indicators are associated with adverse consequences from the disorder.
Eligibility
- Age range
- 15–40 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: HC Inclusion criteria: i. Body mass index ≥ 18.5. ii. Females, ages 15 to 40 years iii. Women of childbearing age: a hormonal (i.e., oral, implantable, or injectable) and single-barrier method, or a double-barrier method of birth control must be used throughout the study. iv. Independently ambulatory v. Possession of a smartphone with data plan vi. English proficiency vii. Willingness and ability to participate in study procedures viii. Provision of signed and dated informed consent form AN Inclusion criteria: i. Primary clinical diagnosis of anorexia nervosa as define…
Interventions
- DeviceVibrant capsule
A capsule delivering mechanical vibrations
Location
- Laureate Institute for Brain ResearchTulsa, Oklahoma