Parathyroid Allotransplantation in Medically Refractory Hypoparathyroidism
University of Alabama at Birmingham
Summary
Options for treatment of severe, refractory hypocalcemia are limited for the thousands of patients in the United States who suffer from hypoparathyroidism. Parathyroid allotransplantation is an emerging treatment that provides hope for these individuals. Currently, this therapy has only been successfully provided by a few centers in the world. In the UAB PATH trial, we propose to become one of the few centers worldwide to successfully achieve parathyroid allotransplantation in transplant-naïve patients.
Description
Hypoparathyroidism (HypoPT) is a clinical condition characterized by hypocalcemia and low parathyroid hormone levels (PTH). HypoPT is most often the result from previous neck surgery such as thyroidectomy, parathyroidectomy and cervical dissection. It can also result in autoimmune damage to parathyroid glands or genetic disorders. Based on analysis of a large health plan claims database, the estimated prevalence of hypoparathyroidism in the United States is 77,000 cases.\[1\] Most patients with symptoms present with neuromuscular irritability such as muscle spam, paresthesia, laryngospasm and…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Individual diagnosed with hypocalcemia secondary to 1. Hypoparathyroidism: 1. Prior anterior cervical neck surgery resulting in hypoparathyroidism 2. Congenital absence or malformation of parathyroid glands during development 2. Presence of hypoparathyroidism for at least one year 3. Failure of medical treatment for hypocalcemia, including need for IV calcium, with negative impact on quality of life and daily function 4. Age 18-80 years 5. Lives in the greater Birmingham region for the duration of the trial 6. Fluent in the English Language 7. W…
Interventions
- ProcedureParathyroid Allotransplant
Patients that meet inclusion criteria and are enrolled in the trial will undergo parathyroid allotransplantation
Location
- University of Alabama at BirminghamBirmingham, Alabama