Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
Ann & Robert H Lurie Children's Hospital of Chicago
Summary
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).
Description
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG). This model system will then be subjected to 1) comprehensive histopathological and molecular characterizations during serial in vivo sub-transplantations; 2) cryopreserved for long term preservation of tumorigenicity; and 3) use…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Pediatric patients with cancer and non-cancer tumor types (solid, liquid, neuro-oncology) * Signed consent for post mortem tissue donation and autopsy Exclusion Criteria: * Signed consent for post mortem tissue donation and autopsy not obtained
Interventions
- OtherCollection of post mortem tissue donation
Collection of post mortem tissue from pediatric participants with cancer and non-cancer tumor types from whom post mortem tissue donation and autopsy consent is obtained.
Location
- Ann & Robert H. Lurie Children's Hospital of ChicagoChicago, Illinois