Study of Platelet Rich Plasma Drops to Moderate Clinically Significant Dry Eye
University of Rochester
Summary
This is a single center double-masked study with up to four visits. Subjects who have been diagnosed with dry-eye syndrome at Flaum Eye Institute will be enrolled. The purpose of the study is to determine if using platelet rich plasma drops can improve clinically significant dry eye in patients and determine if there is a difference with using two different uses of the plasma tear drops: platelet rich plasma tears and plasma tears without platelets.
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Subjects must be diagnosed with clinically significant dry eye. * Subjects have no active ocular disease or allergic conjunctivitis. * Subjects must not be using any topical ocular medications within two weeks prior to enrollment. * Subjects must be willing and able to follow instructions. * Subjects must have voluntarily agreed to participate in the study by signing the statement of informed consent. * Subjects must meet plasma donor criteria as established by University of Rochester Transfusion Medicine \& Blood Bank. Exclusion Criteria: * Is pregnant at the time of…
Interventions
- OtherPlatelet Poor Plasma Tear Drops
Participant blood will be drawn and processed by the University of Rochester Transfusion Medicine and Blood Bank. Processing will isolate the platelet free fraction of the blood plasma. After processing, plasma should contain ≤ 5% concentration of white blood cells (WBC), red blood cells (RBC), and platelets when compared to the concentration before processing.
- OtherPlatelet Rich Plasma Tear Drops
Participant blood will be drawn and processed by the University of Rochester Transfusion Medicine and Blood Bank. Processing will isolate the platelet fraction of the blood plasma. After processing, plasma should contain ≤ 5% concentration of WBC and RBC and 100 x 10³ μl or ≥ 50% recovery of platelets when compared to the pre-platelet count.
Location
- Flaum Eye Institute at the University of RochesterRochester, New York