De-convoluting Interactions Between Genes, the Cancer Environment, and the Immune System to Develop Therapies That Work for You
Weill Medical College of Cornell University
Summary
This is a live biobank study for breast cancer (BC) patients where samples will be collected at inflection points in the course of the disease.
Description
To test this hypothesis the investigators will focus on studying BC patients using an innovative approach, the DIGNITY Study (De-convoluting interactions between genes, the cancer environment, and the immune system to develop therapies that work for you) designed to building a live tissue biobank of Patient Derived Tumor Organoids (PDOs) derived from tumor at surgery, preceded or not by neoadjuvant therapy (NAT), and at recurrence/metastasis. BC patients enrolled in this study are consented to enable investigators to generate a biobank of tumor tissue (obtained from surgically removed excess t…
Eligibility
- Age range
- 18–90 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * All patients will historically proven BC are eligible to be on the study Exclusion Criteria: * Carriers of other cancers other than breast.
Interventions
- ProcedureLive Biobank
Tumor tissue will be collected from consented patients at sequential inflection points in the disease course: at the time of initial diagnosis, at the time of surgery and during recurrence or metastasis. In addition to this, 40ml of research bloods will also be collected at these key inflection points.
Locations (2)
- Brooklyn Methodist Hospital - NewYork PresbyterianNew York, New York
- New York Presbyterian Hospital - QueensNew York, New York