Cardiac Magnetic Resonance for Tissue Characterization-Based Risk Stratification of Cardiopulmonary Symptoms, Effort Tolerance, and Prognosis Among COVID-19 Survivors
Weill Medical College of Cornell University
Summary
The purpose of this study is to test if visualizing the heart with cardiac MRI/echo will be important in the understanding cardiac function and prediction of cardiopulmonary symptoms, physical effort tolerance, and outcomes in COVID-19 survivors. If successful, the research will allow us to identify the causes of lasting cardiopulmonary symptoms and begin developing cardiac and lung directed therapies accordingly.
Description
Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic. Despite substantial short term mortality risk, the overwhelming majority of infected patients survive acute illness, resulting in a growing population at risk for long term events. Cardiopulmonary symptoms are common after COVID-19, as shown by survey data reporting fatigue (53%), dyspnea (43%), and worsened quality of life (44%) 60 days after acute infection, but mechanism and time course of symptoms are unknown. Recent studies and the investigator's preliminary data have shown myocardial tissue abnormalities on cardiac magnet…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Emergency room presentation and/or hospitalization with COVID-19 infection defined in accordance with established criteria as follows: SAR-CoV2 RT-PCR+ (severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction) and at least one of the following symptoms: dyspnea, cough, dysphagia, rhinorrhea, diarrhea, nausea/vomiting, myalgias, fever, syncope/presyncope. Exclusion criteria: * Contraindication to CMR (i.e. non-compatible pacemaker/defibrillator) or gadolinium (known hypersensitivity, eGFR (estimated globular filtration rate) \<30…
Interventions
- Diagnostic TestCardiac MRI
Patients participate in an NIH funded cardiac MRI to assess their symptoms.
- Diagnostic TestEchocardiogram
Patients participate in an NIH funded cardiac echocardiogram to assess their symptoms.
- Diagnostic Test6-minute walk test
Patients participate in a 6-minute walk test to assess their symptoms.
- Diagnostic TestQuestionnaire
Patients answer a survey-based questionnaire to assess their symptoms.
Locations (3)
- New York Presbyterian-Brooklyn Methodist HospitalBrooklyn, New York
- New York Presbyterian QueensNew York, New York
- Weill Cornell Medicine/New-York Presbyterian HospitalNew York, New York