Vaccine Responses in Patients With B Cell Malignancies
National Heart, Lung, and Blood Institute (NHLBI)
Summary
Background: People with B cell malignancies (blood cancers) often cannot mount a full immune response to infections or certain vaccines. Bruton tyrosine kinase inhibitors (BTKis), which are used to treat blood cancers, may also negatively affect a person s response to certain vaccines. Researchers want to learn more about vaccine responses in people with certain types of blood cancers. The findings may help develop better vaccine strategies for people with these cancers. Objective: To learn how well vaccines work in people who have certain types of blood cancers. Eligibility: Adults aged 18 years or older who have chronic lymphocytic leukemia (CLL), Waldenstrom macroglobulinemia, or certain non-Hodgkin lymphomas. Design: Participants will get one or more vaccines for illnesses such as COVID-19, hepatitis B, and shingles. They can choose which vaccines they receive. They will give a blood sample before they get each vaccine. Some vaccines require a second dose 3-6 weeks later. Participants may give an optional blood sample with the second vaccine dose. About 4 weeks after they finish each vaccine series, they will give another blood sample. They will have 2-3 study visits per vaccine. Participants may receive a booster dose for some vaccines. The booster dose is optional. They will give another blood sample with the booster dose. Participants will have pregnancy tests, if needed. Participants with CLL who receive BTKis may be asked to pause treatment for up to 7 weeks. Participants may give follow-up blood samples up to 2 times a year for 5 years. These blood samples are optional. Participation will last for up to 5 years after each vaccine series is received.
Description
Study Description: This study aims to determine vaccine titers in B-cell malignancies; specifically, in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), or other non-Hodgkin lymphomas (NHL) \[follicular lymphoma (FL), mantle cell lymphoma (MCL), marginal zone lymphomas (MZLs) and indolent NHL not otherwise specified (NOS)\], or in Waldenstrom Macroglobulinemia (WM). Note: Since CLL and SLL are considered the same disease, CLL/SLL will be referred to as CLL hereafter, unless otherwise specified. Objectives: Primary Objective: Determine vaccine titers following vaccinatio…
Eligibility
- Age range
- 18–90 years
- Sex
- All
- Healthy volunteers
- No
* INCLUSION CRITERIA: * Diagnosis of CLL, FL, MCL, MZL, NHL NOS or WM * Must fulfil one of the following criteria to be enrolled in one study arm per vaccine received: 1. Patients with CLL AND one of the following: i. Arm 1: Must be treatment naive (no prior cancer directed therapy) ii. Arm 2: Patients that have received prior cancer directed therapy and are currently not receiving active treatment iii. Arm 3: Must be receiving treatment with a BTKi. This arm is not available to patients receiving the HEPLISAV-B vaccine iv. Arm 4: Must be receiving treatment with a B…
Interventions
- BiologicalFluzone
Annual Influenza Vaccine
- BiologicalShingrix
Recombinant, adjuvanted Zoster Vaccine (RZV)
- BiologicalFlucelvax
Annual Influenza Vaccine
- BiologicalAfluria
Annual Influenza Vaccine
- BiologicalPREVNAR 13
Pneumococcal Conjugate Vaccine (PCV13)
- BiologicalHeplisav -B
Recombinant, adjuvanted Hepatitis (HepB-CpG)
- BiologicalPfizer-COVID-19 Vaccine
COVID-19 Vaccine
Location
- National Institutes of Health Clinical CenterBethesda, Maryland