Molecular Epidemiology of Biliary Tree Cancers
M.D. Anderson Cancer Center
Summary
This study is to learn if certain risk factors (environmental, viral, behavioral, medical, and dietary), tumor markers, and genetic changes can predict the development and outcome of biliary tree cancers. Establishing biomarkers models from patients may help doctors to further understand how biliary tree cancer is affected by different treatments, and why some people's cancer responds differently than others.
Description
PRIMARY OBJECTIVES: I. To identify significant factors that may contribute to the etiology of biliary tree cancer. II. To identify novel genetic loci that predispose to gallbladder cancers (GBC) and cholangiocarcinoma (CGC) diagnosis. EXPLORATORY AND CORRELATIVE OBJECTIVES: I. To use the collected blood and tissue materials for exploratory analysis to identify markers that predict prognosis of biliary tree cancers. II. To correlate the identified markers with results of specific aim I and II to test the interaction between the identified markers with environmental and genetic factors. OU…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: * Pathologically or radiologically confirmed diagnosis of CGC or GBC * With or without prior radiation or chemotherapy * All United States of America (USA) and non USA residents * No age, gender, or racial restriction * Healthy control with no current or history of cancer * Healthy controls are USA and non USA residents * Healthy controls are matched to the cases in age (5 years), gender, and race * Healthy controls are friends and spouses of patients with other than gastro-intestinal (GI) cancers * Chronic Liver Disease (CLD) controls with no current or history of cancer…
Interventions
- ProcedureBiospecimen Collection
Undergo collection of tissue, and blood
- OtherQuestionnaire Administration
Complete questionnaire
Location
- M D Anderson Cancer CenterHouston, Texas