Extra-Cellular Hemoglobin, Organ Injury in Extended Cardiopulmonary Bypass
University of Maryland, Baltimore
Summary
Studying the dynamics of red blood cell lysis, pfH, protective proteins and organ injury, limits will be set for safe levels of pfH following the use of CPB. These results will be compared to existing laboratory-based methods for determining red blood cell damage to predict CPB assist device safety. Further, results from the studies described in this proposal will help develop therapeutic strategies to benefit patients by early detection of pfH and clearance protein levels that occur during CPB.
Description
Cost estimates for brain, lung, cardiac, and kidney complications following complex cardiac surgeries that require a medical assist device to by-pass the heart and lungs (cardiopulmonary bypass, CPB) is estimated to cost $80 million per individual states in the US over a ten-year period. These extra costs represent a significant burden on the healthcare system but could be reduced by understanding how medical assist devices lead to organ injury associated with complex cardiac surgeries. The primary goals of this research are to (1) understand how hemoglobin released into plasma (pfH) from dama…
Eligibility
- Age range
- 18–88 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Admitted to UMMC for cardiac procedure * Age: \>/=18 y.o TO 88 y.o. * Undergoing CPB \>1hr for the following surgeries (a) complex cardiac surgery (b) heart valve replacement surgery OR (c) CABG surgery. Exclusion Criteria: * Pregnant * Non English speaking * Unable to consent or have Legally Authorized Representative (LAR) assent to study
Interventions
- OtherBlood and urine collection
No intervention - Biological specimen collection
Location
- Center for Blood Oxygen Transport and HemostasisBaltimore, Maryland