Preoperative Y-90 Radioembolization for Tumor Control and Future Liver Remnant Hypertrophy in Patients With Colorectal Liver Metastases
M.D. Anderson Cancer Center
Summary
A prospective, interventional study evaluating the safety of Y-90 TARE for tumor control of the right side and induction of left liver hypertrophy as part of a planned single-stage or two-stage hepatectomy for patients with CLM and insufficient FLR at the time of presentation.
Description
Primary Objective: To examine the safety and feasibility of Y-90 TARE directed to the right hemi-liver for induction of left liver FLR hypertrophy as part of a planned hepatectomy for patients with CLM. Secondary Objectives: * To describe changes in liver volume after Y-90 TARE, including: * The kinetic growth rate (KGR) of the FLR * Degree of hypertrophy 6 weeks after TARE * Atrophy of targeted right hemi-liver from TARE date to date of surgery * To describe additional interventional procedures needed to induce additional hypertrophy if insufficient hypertrophy from Y-90 TARE * To a…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Borderline resectable unresectable (due to insufficient liver volume at presentation) colorectal liver metastases with potential curative intent, as determined by the surgeon and multidisciplinary team * Anticipated standardized FLR (sFLR) that would require right portal vein embolization (PVE) to increase the sFLR prior to either a single major hepatectomy, or prior to the second stage hepatectomy as part of a two-stage hepatectomy strategy, all in the setting of curative-intent resection(s). This evaluation will be documented in the clinical chart * Received at least f…
Interventions
- DrugYttrium-90 (Y-90) resin microspheres
Given by scan
Location
- M D Anderson Cancer CenterHouston, Texas