Investigating the Longitudinal Relationships Between Visual Pathway Injury, Radiological and Blood Biomarkers in Multiple Sclerosis and Related Disorders
Cedars-Sinai Medical Center
Summary
This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in quantitative disability measures related to MSRD and neurological disease.
Description
Screening: Prospective participants will be screened at Cedars-Sinai Medical Center (CSMC) through a comprehensive review of their medical and MRI records done as part of standard of care to determine if they are eligible to participate in this study. If they never had an MRI at CSMC, they will be asked to provide records of an MRI done at another site. If the study team determines that they are eligible to continue participating, then they will move on to the main research study. Main Research Study: The following items will be collected as part of the main research study: * Demographic d…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Subjects who meet any one of the following diagnostic criteria: * Diagnosis of MS, CIS,or RIS based on the 2017 revised McDonald criteria. * Diagnosis of NMOSD based on the 2015 revised NMOSD consensus diagnostic criteria. * Diagnosis of myelin oligodendrocyte glycoprotein (MOG)-related encephalomyelitis, optic neuritis, or other associated disease. * Diagnosis of neurological disorders other than MSRD. * Healthy volunteer. * Age ≥18. * Able to give informed consent. Exclusion Criteria: * Patients will be excluded from the MRI portions of the study if they h…
Location
- Cedars-Sinai Medical CenterLos Angeles, California