University of Pittsburgh
The purpose of this study is to better understand cortical contributions of the human temporal lobe to the frequency-following response. Frequency-following responses (FFR) are electrophysiological recordings that reflect phase-locked activity of neural ensembles in the auditory pathway and are used as an indicator of the integrity of supra-threshold speech processing. FFR was first studied in subcortical areas, but recent consensus in the literature supports the notion that it is an integrated response between subcortical and cortical neural populations. The proposed study aims to deconstruct the role of the cortex in generating and modulating the FFR. The research team will build a novel computational model of FFR mechanisms and use EEG recordings from participants who have undergone resection of lesions in Heschl's gyrus to validate model predictions.
The purpose of this study is to better understand the cortical contribution of the human temporal lobe to the generation and modulation of frequency-following responses (FFR). The specific aims of this study is as follows: 1. To build a novel computational model of cortical feedforward mechanisms involved in FFRs. 2. To test model predictions of cortical removal in human participants who have undergone surgical resection of Heschl's gyrus lesions. The hypothesis to be tested for the previously listed purposes and aims are as follows: 1\. When cortical areas involved in generating and modul…
Inclusion Criteria: * Individuals 13-25 years old * Undergoing medically necessary surgical resection of Heschl's gyrus lesion * Monolingual English speakers * Receptive and expressive language within normal limits * Normal or corrected-to-normal visual acuity * Normal hearing acuity in each ear (as determined during an audiometric assessment) * Nonverbal IQ within normal limits * No history of autism spectrum disorder or attention-deficit hyperactivity disorder Exclusion Criteria: * Significant medical or neuropsychological impairment that would result in the patient being unable to partic…
Participants will listen to repetitive speech sound stimuli, presented through headphones, which will induce a neural response (frequency-following response) to be measured via electroencephalography and pupillometry
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