Metabolic and Functional Consequences of Aging in Health and Disease
Texas A&M University
Summary
Considerable heterogeneity in the aging population has been observed. The exceptional longevity of individuals reaching 100 years old, so-called centenarians may be an example of life-long healthy aging, or added years may be spent in poor health with decreased physical and cognitive functioning. Current knowledge of the aging experience and the trajectories of physical and cognitive decline across various age groups are not well-understood, yet crucial to prevent spending added years in disease. Hence, the study objective is to develop the metabolic profile associated with aging-related disorders measured as the incidence of impaired functional capacity, cognitive function, and/or well-being.
Description
Our lab developed a pulse method combining multiple stable tracers to study multiple metabolic pathways in the same individual simultaneously. By measuring whole-body metabolism in a large group of older adults, we may be able to unravel age-related deterioration in protein turnover (synthesis and breakdown) that contributes to impaired functional capacity. Metabolic profiles could explain differences in pathways in the aging process with a special interest in the metabolism of amino acids as they have been associated with aging-related disorders. Studies on the effect of aging on metabolism m…
Eligibility
- Age range
- 50+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Stable body-weight (± 5%) for the past 3 months * Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations. * Ability to walk, sit down and stand up independently or with walking mobility aids * Ability to lie in a supine or elevated position for up to 3 hours * Willingness and ability to comply with the protocol Exclusion Criteria: * Insulin dependent diabetes mellitus * Established diagnosis of malignancy * History of untreated metabolic diseases including hepatic or renal disorder * Presence…
Interventions
- OtherStable tracer infusion in a postabsorptive state
Multiple stable-labeled tracers of amino acids, ketoacids, glycerol, short-chain fatty acids
Location
- Human Clinical Research BuildingCollege Station, Texas