The University of Texas Health Science Center, Houston
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation. Smoking and brain functional connectivity changes will be assessed at baseline, different stages of rTMS and/or follow-ups.
Neuroimaging studies suggest that high rate of smoking in patients with schizophrenia may be due to an overlap of nicotine addiction-related circuitries and schizophrenia-related circuitries, such that schizophrenia impacts some of the same circuitries that increase risks for severe nicotine addiction in general. Those identified overlapping circuitries have been linked to several key features of nicotine addiction and can be represented by resting-state functional connectivities. The investigators aim to develop a TMS method targeting special brain circuits that are both smoking cessation and…
Inclusion Criteria: 1. Male and female between ages 22-65 years 2. Ability to give written informed consent 3. Smoking in the last one year or more and average cigarette per day ≥ 5 in the past 4 weeks 4. Diagnosed with schizophrenia-spectrum disorder and Evaluation to Sign Consent (ESC) above10. 5. Is currently under the care of a licensed primary care provider or mental healthcare provider (e.g., psychiatrist, psychologist, nurse practitioner, licensed clinical social worker). 6. Agrees to: (a) provide written permission, as requested, to allow any and all forms of communication between the…
Multiple trains of rTMS in a day, for multiple days.
Multiple trains of rTMS in a day, for multiple days.
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