Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care
Arkansas Children's Hospital Research Institute
Summary
this study is aiming at learning more about primary ciliary dyskinesia (PCD) and tests that are used to diagnose this condition. One purpose of this study is to measure the level of nitric oxide in the nasal passages and examine how often the results correlate with other tests currently done to make the diagnosis.
Description
This will be an observational study. Participants who are referred by their clinician for nasal NO testing and meet the inclusion and exclusion criteria will be allowed to undergo testing. Informed consent will be completed prior to testing. The participant and/or guardian will be informed that this testing is not a clinically approved test at this time and thus it cannot confirm diagnosis of PCD. This test is to correlate with other diagnostic tests so that in the future it can be an approved diagnostic test. Data will be collected from the electronic medical records regarding participants.…
Eligibility
- Age range
- 2–99 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Individuals who are diagnosed with Primary Ciliary Dyskinesia OR * Individuals with abnormal PCD diagnostics (abnormal ciliary biopsy or PCD genetics) OR * Individuals with unexplained bronchiectasis OR * Individuals undergoing PCD diagnostic testing (ciliary biopsy, PCD genetic testing) or concern based on clinical symptoms (at least two of the following): * Neonatal respiratory distress * Organ laterality defects * Year-round cough starting in first year of life or bronchiectasis on chest CT * Year-round nasal congestion starting in first year of life or pansi…
Location
- Arkansas Children's HospitalLittle Rock, Arkansas