Pilot Feasibility Trial of Dietary and Topical Magnesium Replacement or Supplementation in Patients With Lymphoma
Mayo Clinic
Summary
This early phase I trial investigates the effect of dietary and topical magnesium replacement on magnesium blood levels in patients with lymphoma. Magnesium is an element in the body that is important to cell health. The body cannot make magnesium and it typically comes from the food we eat. In patients who are ill, magnesium is often replaced intravenously (IV) through a vein or by mouth. This study may help researchers find out if being on a magnesium rich diet and using a magnesium lotion on the skin helps to keep magnesium blood levels in an ideal range. This study also investigates side effects and quality of life when receiving different forms of magnesium.
Description
PRIMARY OBJECTIVE: I. Assess if dietary replacement with magnesium rich foods and topical magnesium replacement improves serum magnesium levels in patients with a history of a lymphoproliferative disorder, not on active myelosuppressive chemotherapy, and have a serum magnesium levels 1.5 - 1.9 mg/dL. SECONDARY OBJECTIVES: I. Evaluate the compliance of a diet rich in magnesium as well as compliance with topical magnesium replacement in lymphoma patients who have completed therapy and are in remission. II. Assess feasibility of enrolling patients with a history of lymphoproliferative disorde…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: PRE-REGISTRATION - INCLUSION CRITERIA: * Age \>= 18 years * Currently have or have had in the past the diagnosis of any type of lymphoma * If previously treated, the patient must be off myelosuppressive chemotherapy with no planned chemotherapy for \>= 2 months. Patients with lymphoproliferative disorders being observed (i.e., never treated) or those on rituximab (or equivalent) maintenance or chronic oral therapies such as BTK inhibitors, venetoclax, tazemetostat, or corticosteroids are also eligible * Able to eat a full range of solid food and liquids and tolerate seeds…
Interventions
- DrugMagnesium Chloride-based Lotion
Given topically
- OtherQuality-of-Life Assessment
Ancillary studies
- BehavioralSpecial Diet Therapy
Consume magnesium rich foods
Location
- Mayo Clinic in RochesterRochester, Minnesota