VA Office of Research and Development
This research will develop novel and accessible way to deliver effective and customized rehab to those suffering from common and devastating neurodegenerative condition called Parkinson's disease. The investigators will examine the efficacy of novel rehab technique that can be monitored and modified in real-time but over virtual interface using a remotely located device in a paradigm called dynamic cycling. This technology will benefit thousands of Veterans who need customized and cost-effective rehab but cannot travel to specialized facilities due to inevitable limitations such as pandemics or because of lack of resources, social support, frailty, or home-bound status.
Parkinson's disease (PD) progressively deteriorates motor function. Successful rehabilitation, leading to a favorable course of movement disorders in PD, is contingent upon frequent, regular, and patient-specific exercise regimen that is customized to the individual needs. Latter requires regular interventions from the provider and frequent visits to the rehab facility. Lack of access, poor social support, inability to travel, home-bound status, or pandemics are significant hurdles in delivering effective rehab to the PD patients. The investigators' vision is to offer customized and cost-effec…
Inclusion Criteria: Diagnosis of PD using the UK Brain Bank criteria * Ability to perform informed consent. * Hoehn and Yahr (H\&Y) stages I-III when off medication, * Stable medical regimen of antiparkinsonian medication for at least six months Exclusion Criteria: * Montreal Cognitive Assessment Scoreless than 18 * Hamilton depression score of 20 or higher * Hamilton anxiety rating score greater than 24 * Clinical diagnosis including perinatal brain injury, stroke, and atypical parkinsonism * One or more signs or symptoms of untreated cardiovascular disease including Pain, discomfort in t…
The dynamic cycling involves smart bike that changes according to participants' performance.
The same smart bike as used for dynamic cycling, but its adaptive capacity will be disabled. In this case, the bike will behave as standard exercise stationary bike. It will not change its performance according to participants' response.
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