In Vivo Detection of Circulating Clots in Patients With Thromboembolism
University of Arkansas
Summary
Subjects with thromboembolic disease or at high-risk for thromboembolic conditions diagnosed with ultrasound or other standard of care techniques will be recruited to estimate the feasibility of a device to detect in vivo CBCs.
Description
There are no current gold standards to detect circulating blood clots. The sensitivity of most current methods to detect CBCs is poor when low numbers are present in the host. A novel method of detecting circulating blood clots, PAFC, may improve detection of CBCs and, if so, ultimately may reduce complications related to previously undetected clots.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria * Men and women, 18 years old and older. * Evidence of current venous or arterial thromboembolic disease diagnosed by standard of care clinical, radiographic, or laboratory testing or acute ischemic stroke. * Informed consent provided by the subject. Exclusion Criteria * Pulmonary embolus with a need for mechanical ventilation or other ventilator support (may be on oxygen delivered by nasal cannula or mask at an FiO2 of ≤ 0.40) * Acute coronary syndrome (including unstable angina) * Significant cardiac arrhythmia (may have atrial fibrillation controlled with medication) *…
Interventions
- DevicePhotoacoustic Flow Cytometry
Detection of circulating blood clots
Location
- Univerisity of Arkansas for Medical SciencesLittle Rock, Arkansas