Massachusetts General Hospital
This proposal aims to study the role that the dorsal prefrontal cortex plays in human social cognition.
Despite ongoing progress in the understanding of social behavior, little is known about the single-neuronal mechanisms that underlie human social cognition. The investigators will obtain single-neuronal recordings from the prefrontal cortex in participants undergoing clinically planned deep brain stimulation (DBS) electrode placement. The study population will consist of subjects undergoing planned DBS placement. Prospective participants will be selected for surgery irrespective of their participation in the study. After consenting to the study, the participants will be allowed to withdraw fr…
Inclusion Criteria: 1. 18 years old or older 2. patients able to give informed consent Exclusion Criteria: 1. Children under 18 2. Significant co-morbidities 3. Claustrophobia or general anxiety that may impact intraoperative testing 4. Use of CNS-active medications including stimulants and antipsychotics which may alter 5. Pregnancy 6. Operative events that will require expedition of the surgery. 7. Poor tolerance of testing by the patient 8. Increased abnormal cortical excitability 9. Necessity to administer drugs that will interfere with mapping
Participants undergoing clinically planned neurosurgical procedures will undergo single-neuronal recordings as they perform brief behavioral tasks.
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