Individualizing Corticosteroid Use in Pneumonia
Mayo Clinic
Summary
In this study, researchers propose a unique (individualized) approach to steroid treatment seeking to give the right dose of steroid to the right patient and at the right time. This study seeks to compare usual care to an individualized steroid dosing strategy by testing a marker of inflammation in the blood called C- reactive protein (CRP). The overall goal is to reduce an individual's exposure to steroids and the risk of potential side effects thereby increasing the potential benefit of using steroids to control inflammation in pneumonia.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Hospitalized adult (≥ 18 years) patients. * Community acquired pneumonia. Exclusion Criteria: * Contraindications or unwillingness to use corticosteroids by patient or provider. * History of adrenal insufficiency, septic shock, or another absolute indication for steroid use. * Suspected pulmonary vasculitis or other autoimmune pulmonary disorder. * Positive pregnancy test * Comfort care.
Interventions
- DrugDexamethasone
Administered intravenously or orally based on daily CRP values and CRP corticosteroid dosing algorithm
Location
- Mayo Clinic RochesterRochester, Minnesota