The Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) Intervention: A Randomized Controlled Trial for Adolescents With Sickle Cell Disease to Prepare for Transition of Care
University of Alabama at Birmingham
Summary
Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for transition of care.
Description
Cognitive impairment is a pervasive debilitating feature of sickle cell disease (SCD), with over 50% of children demonstrating early neurodevelopmental delays, ultimately influencing ability for adolescents with SCD to engage in effective decision-making needed for successful transition into adulthood. The negative effect of cognitive impairment on transition to adult self-care is further compounded by health-related disparities and poor social determinants of health. Transition to self-care among youth with SCD may be facilitated by cognitive remediation. One potential avenue to disseminate c…
Eligibility
- Age range
- 10–18 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosis of SCD (all genotypes) * Active follow-up at Children's of Alabama Hospital * Ages 10-18 * English-speaking Exclusion Criteria: * History of seizures or overt stroke * History of Intellectual Disability or Autism Spectrum Disorder * Inability to participate in the MRI scan, such as metal implants, neurostimulators, claustrophobia * Currently on psychotropic medications
Interventions
- BehavioralCREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
Manualized cognitive remediation intervention that includes 1) skills-based remediation (metacognitive training), 2) parent training, and 3) cognitive behavioral approaches. Intervention targets self-management and goal-setting skill building to promote independence in activities necessary for transition of care.
Location
- University of Alabama at BirminghamBirmingham, Alabama