Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia (A Sub-Study)
University of Colorado, Denver
Summary
The purpose of this study is to determine if taking iron supplement pills improves exercise performance in low-oxygen conditions.
Description
Hypoxia (low oxygen) causes the blood vessels in the lungs to constrict (hypoxic pulmonary vasoconstriction). This increases the pressure (afterload) the right ventricle faces as it pumps blood to the lungs. Increased right ventricular afterload during hypoxia may compromise exercise capacity. Intravenous iron administration prior to hypoxic exposure has been shown to blunt the hypoxia-induced increase in right ventricular afterload. This may be through iron's action in the Hypoxia Inducible Factor (HIF) pathway. Iron is a cofactor for prolyl hydroxylases that degrade HIF subunits and thus may…
Eligibility
- Age range
- 18–60 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age 18 - 60 * For women, premenopausal status Exclusion Criteria: * Active cardiovascular or pulmonary disease (e.g. hypertension, coronary artery disease, cardiomyopathy, arrhythmia, valvular abnormalities, diabetes, peripheral vascular disease, tobacco use, chronic obstructive pulmonary disease, asthma, interstitial lung disease, restrictive lung disease, or pulmonary hypertension) * Use of cardiac- or pulmonary-related medications * Prior history of high altitude pulmonary edema or high altitude cerebral edema * Body mass index \< 18.5 or \> 30 * Anemia * Iron defic…
Interventions
- DrugFerrous sulfate 325mg
Participants will take one tab of ferrous sulfate 325 mg (equivalent to 65 mg elemental iron) daily for 30 days.
Location
- University of Colorado Anschutz Medical CampusAurora, Colorado