Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women
Florida State University
Summary
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.
Description
The primary objective is to compare the effects of 12 weeks of resistance training to endurance training with respect to whole-body and regional lipolytic (fat breakdown) responses to acute walking exercise, (Aim 1), local adrenergic receptor blockade (Aim 2) and in response to insulin during a hyperinsulinemic-euglycemic clamp (Aim 3). The investigators will study the lipolytic response in the context of acute exercise, whole-body fat oxidation and resting energy expenditure data. The investigators will collect data on chronic lipogenesis (fat synthesis) and adipogenesis (fat cell formation),…
Eligibility
- Age range
- 50–75 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Women * Postmenopausal (50-75 yrs.) * Obese (BMI 30-50 kg/m2) * Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL) * Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week) * Non-smokers * No hormone replacement therapy for at least the past two years. Exclusion Criteria: * Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week) * Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic * Type 1 or type 2 diabete…
Interventions
- BehavioralResistance Exercise
200 Kcal worth of weightlifting, 3 times/week for 12 weeks
- BehavioralEndurance Exercise
200 Kcal worth of treadmill walking, 3 times/week for 12 weeks
Location
- Florida State UniversityTallahassee, Florida