Recording of Intraoperative Spinal Cord Stimulation and Monitoring
University of California, Los Angeles
Summary
Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Any patients undergoing brain or spinal cord surgery where spinal neuromonitoring is utilized. Exclusion Criteria: * none
Interventions
- Deviceepidural electrical stimulation
Electrical spinal cord stimulation will be used to modulate respiratory function during general anesthesia.
Location
- University of California, Los AngelesLos Angeles, California